The role of naturally acquired antimalarial antibodies in subclinical Plasmodium spp. infection

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Katherine O'Flaherty¹  Merryn Roe¹  Freya J.I. Fowkes¹ 

[1] Disease Elimination Program, Burnet Institute for Medical Research and Public Health;School of Public Health and Preventive Medicine, Monash University;Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne;Department of Infectious Disease, Monash University

关键词: Epidemiology;    Malaria;    Parasitic;    Immune Response;    Antibodies;    Adaptive Immunity;   

DOI  :  10.1002/JLB.5MR1021-537R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Undetected subclinical Plasmodium spp. infections are a significant barrier to eliminating malaria. In malaria-endemic areas, naturally acquired antimalarial antibodies develop with repeated infection. These antibodies can confer protection against the clinical manifestations of Plasmodium spp. infection in highly exposed populations, and several distinct functional antibody mechanisms have been defined in the clearance of Plasmodium parasites. However, the role of antimalarial antibodies during subclinical infection is less well defined. In this review, we examine the development and maintenance of antibody responses and the functional mechanisms associated with clinical protection, highlighted by epidemiological studies investigating the association between human immunity and detection of subclinical infection across various malaria transmission intensities. Understanding the development and role of the antimalarial antibody response during subclinical Plasmodium spp. infection will be essential to furthering novel interventions including vaccines and immunological biomarkers that can be utilized for malaria surveillance and ultimately progress malaria elimination.

【 授权许可】

CC BY