Cellular immune responses in the pathophysiology of preeclampsia

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Derek Miller¹  Kenichiro Motomura¹  Jose Galaz¹  Meyer Gershater¹  Eun D. Lee³  Roberto Romero¹  Nardhy Gomez-Lopez¹ 

[1] Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services;Department of Obstetrics and Gynecology, Wayne State University School of Medicine;Department of Microbiology and Immunology, Virginia Commonwealth University;Department of Obstetrics and Gynecology, Virginia Commonwealth University;Department of Obstetrics and Gynecology, University of Michigan;Department of Epidemiology and Biostatistics, Michigan State University;Center for Molecular Medicine and Genetics, Wayne State University;Detroit Medical Center;Department of Obstetrics and Gynecology, Florida International University;Department of Biochemistry, Microbiology, and Immunology, Wayne State University School of Medicine

关键词: gestational hypertension;    hypertensive disorders of pregnancy (HDP);    immune cell;    macrophage;    monocyte;    natural killer cell;    neutrophil;    NK cell;    pregnancy;    regulatory T cell;    T cell;   

DOI  :  10.1002/JLB.5RU1120-787RR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Preeclampsia, defined as new-onset hypertension accompanied by proteinuria occurring at 20 weeks of gestation or later, is a leading cause of perinatal morbidity and mortality worldwide. The pathophysiology of this major multi-systemic syndrome includes defective deep placentation, oxidative stress, endothelial dysfunction, the presence of an anti-angiogenic state, and intravascular inflammation, among others. In this review, we provide a comprehensive overview of the cellular immune responses involved in the pathogenesis of preeclampsia. Specifically, we summarize the role of innate and adaptive immune cells in the maternal circulation, reproductive tissues, and at the maternal-fetal interface of women affected by this pregnancy complication. The major cellular subsets involved in the pathogenesis of preeclampsia are regulatory T cells, effector T cells, NK cells, monocytes, macrophages, and neutrophils. We also summarize the literature on those immune cells that have been less characterized in this clinical condition, such as γδ T cells, invariant natural killer T cells, dendritic cells, mast cells, and B cells. Moreover, we discuss in vivo studies utilizing a variety of animal models of preeclampsia to further support the role of immune cells in this disease. Finally, we highlight the existing gaps in knowledge of the immunobiology of preeclampsia that require further investigation. The goal of this review is to promote translational research leading to clinically relevant strategies that can improve adverse perinatal outcomes resulting from the obstetrical syndrome of preeclampsia.

【 授权许可】

CC BY