Research advances in nanomedicine, immunotherapy, and combination therapy for leukemia

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

article

Zhuoya Wan¹  Runzi Sun²  Pearl Moharil³  Jing Chen¹  Yuzhe Liu⁵  Xu Song¹  Qiang Ao¹ 

[1] Institute of Regulatory Science for Medical Device, National Engineering Research Center for Biomaterials, Sichuan University;Department of Immunology, School of Medicine, University of Pittsburgh;Department of Cell Biology, Harvard Medical School, Harvard University;Department of Pharmaceutical Science, School of Pharmacy, University of Pittsburgh;Department of Materials Engineering, Purdue University

关键词: nanotechnology;    immunotherapy;    cancer;    hematology;   

DOI  :  10.1002/JLB.5MR0620-063RR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

In the past decade, clinical and laboratory studies have led to important new insights into the biology of leukemia and its treatment. This review describes the progress of leukemia research in the United States in recent years. Whereas the traditional method of treatment is chemotherapy, it is nonselective and could induce systemic toxicities. Thus, in parallel with research on new chemotherapies, great emphasis has been placed on developing immunotherapies. Here, we will review the current immunotherapies available in research and development that overcome current challenges, specifically looking in the field of chimeric antigen receptor T-cell (CAR-T) therapies, checkpoint inhibitors, and antibody-drug conjugates. With about 100 clinical trials for CAR-T therapies and 30 in checkpoint inhibitors for leukemia treatment, scientists are trying to make these technologies cheaper, faster, and more feasible. Further describing the delivery of these therapeutics, we look at the current progress, clinical, and preclinical status of nano-based medicines such as liposomes, polymeric micelles, and metal nanoparticles. Taking advantage of their physicochemical and biologic properties, nanoparticles have been shown to increase the efficacy of commonly administered chemotherapies with reduced adverse effects.

【 授权许可】

CC BY