Genetic, metabolic and immunological features of cancers with NRF2 addiction

FEBS Letters

article

Hiroshi Kitamura¹  Haruna Takeda¹  Hozumi Motohashi¹ 

[1] Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University

关键词: cancer stemness;    CEBPB;    immunoevasion;    KEAP1;    malignancy;    metabolic reprogramming;    non-small cell lung cancer;    NOTCH3;    NRF2;    pentose phosphate pathway;   

DOI  :  10.1002/1873-3468.14458

来源: John Wiley & Sons Ltd.

【 摘 要 】

Nuclear factor erythroid-derived 2-like 2 (NRF2) is a master transcription factor that coordinately regulates the expression of many cytoprotective genes and plays a central role in defense mechanisms against oxidative and electrophilic insults. Although increased NRF2 activity is principally beneficial for our health, NRF2 activation in cancer cells is detrimental. Many human cancers exhibit persistent NRF2 activation and such cancer cells rely on NRF2 for most of their malignant characteristics, such as therapeutic resistance and aggressive tumourigenesis, and thus fall into NRF2 addiction. The persistent activation of NRF2 confers great advantages on cancer cells, whereas it is not tolerated by normal cells, suggesting that certain requirements are necessary for a cell to exploit NRF2 and evolve into malignant cancer cells. In this review, recent reports and data on the genetic, metabolic and immunological features of NRF2-activated cancer cells are summarized, and prerequisites for NRF2 addiction in cancer cells and their therapeutic applications are discussed.

【 授权许可】

Unknown