Multiorgan microphysiological systems as tools to interrogate interorgan crosstalk and complex diseases

FEBS Letters

article

Martin Trapecar¹ 

[1] Department of Medicine, Johns Hopkins University School of Medicine, Institute for Fundamental Biomedical Research, Johns Hopkins All Children's Hospital;Department of Biomedical Engineering, Johns Hopkins University

关键词: complex diseases;    human physiology;    in vitro model;    interorgan communication;    microphysiological systems;    multiorgan crosstalk;    organ-on-a-chip;    systems biology;    tissue chip;    tissue engineering;   

DOI  :  10.1002/1873-3468.14260

来源: John Wiley & Sons Ltd.

【 摘 要 】

Metabolic and inflammatory disorders such as autoimmune and neurodegenerative diseases are increasing at alarming rates. Many of these are not tissue-specific occurrences but complex, systemic pathologies of unknown origin for which no cure exists. Such complexity obscures causal relationships among factors regulating disease progression. Emerging technologies mimicking human physiology, such as microphysiological systems (MPSs), offer new possibilities to provide clarity in systemic metabolic and inflammatory diseases. Controlled interaction of multiple MPSs and the scalability of biological complexity in MPSs, supported by continuous multiomic monitoring, might hold the key to identifying novel relationships between interorgan crosstalk, metabolism, and immunity. In this perspective, I aim to discuss the current state of modeling multiorgan physiology and evaluate current opportunities and challenges.

【 授权许可】

Unknown