Osteocalcin and the physiology of danger

FEBS Letters

article

Julian Meyer Berger¹  Gerard Karsenty¹ 

[1] Department of Genetics and Development, Vagelos College of Physicians and Surgeons, Columbia University

关键词: inter-organ communication;    osteocalcin;    response to danger;    skeleton;   

DOI  :  10.1002/1873-3468.14259

来源: John Wiley & Sons Ltd.

【 摘 要 】

Bone biology has long been driven by the question as to what molecules affect cell differentiation or the functions of bone. Exploring this issue has been an extraordinarily powerful way to improve our knowledge of bone development and physiology. More recently, a second question has emerged: does bone have other functions besides making bone? Addressing this conundrum revealed that the bone-derived hormone osteocalcin affects a surprisingly large number of organs and physiological processes, including acute stress response. This review will focus on this emerging aspect of bone biology taking osteocalcin as a case study and will show how classical and endocrine functions of bone help to define a new functional identity for this tissue.

【 授权许可】

Unknown