The role of exosomes in intercellular and inter-organ communication of the peripheral nervous system

FEBS Letters

article

Julia Patricia Bischoff¹  Alexander Schulz¹  Helen Morrison¹ 

[1] Leibniz Institute on Aging, Fritz Lipmann Institute;Institute of Biochemistry and Biophysics, Friedrich-Schiller-University Jena;Faculty of Biological Sciences, Friedrich Schiller University Jena

关键词: exosome;    homeostasis;    intercellular communication;    PNS;    regeneration;   

DOI  :  10.1002/1873-3468.14274

来源: John Wiley & Sons Ltd.

【 摘 要 】

Exosomes, nano-sized extracellular vesicles, are produced via the endosomal pathway and released in the extracellular space upon fusion of multivesicular bodies with the plasma membrane. Recent evidence shows that these extracellular vesicles play a key role in cell-to-cell communication. Exosomes transport bioactive proteins, mRNAs, and microRNA (miRNAs) in an active form to adjacent cells or to distant organs. In this review, we focus on the role of exosomes in peripheral nerve maintenance and repair, as well as peripheral nerve/organ crosstalk, and discuss the potential benefits of exploiting exosomes for treating PNS injuries. In addition, we will highlight the emerging role of exosomes as new important vehicles for physiological systemic crosstalk failures, which could lead to organ dysfunction during neuroinflammation or aging.

【 授权许可】

Unknown