Fibroblast-mediated intercellular crosstalk in the healthy and diseased heart

FEBS Letters

article

Luka Nicin¹  Julian U. G. Wagner¹  Guillermo Luxán¹  Stefanie Dimmeler¹ 

[1] Institute for Cardiovascular Regeneration, Goethe University;German Center for Cardiovascular Research;Cardio-Pulmonary Institute

关键词: aging;    cardiomyocytes;    cardiovascular disease;    electrical coupling;    endothelial cells;    exosomes;    fibroblasts;    heart;    immune cells;    paracrine signaling;   

DOI  :  10.1002/1873-3468.14234

来源: John Wiley & Sons Ltd.

【 摘 要 】

Cardiac fibroblasts constitute a major cell population in the heart. They secrete extracellular matrix components and various other factors shaping the microenvironment of the heart. In silico analysis of intercellular communication based on single-cell RNA sequencing revealed that fibroblasts are the source of the majority of outgoing signals to other cell types. This observation suggests that fibroblasts play key roles in orchestrating cellular interactions that maintain organ homeostasis but that can also contribute to disease states. Here, we will review the current knowledge of fibroblast interactions in the healthy, diseased, and aging heart. We focus on the interactions that fibroblasts establish with other cells of the heart, specifically cardiomyocytes, endothelial cells and immune cells, and particularly those relying on paracrine, electrical, and exosomal communication modes.

【 授权许可】

Unknown