Interorgan crosstalk in pancreatic islet function and pathology

FEBS Letters

article

Ronald M. Evans¹  Zong Wei² 

[1] Gene Expression Laboratory, Salk Institute for Biological Studies;Department of Physiology and Biomedical Engineering, Mayo Clinic Arizona

关键词: GLP-1;    inter-organ crosstalk;    pancreatic β cells;    type 2 diabetes mellitus;   

DOI  :  10.1002/1873-3468.14282

来源: John Wiley & Sons Ltd.

【 摘 要 】

Pancreatic β cells secrete insulin in response to glucose, a process that is regulated at multiple levels, including a network of input signals from other organ systems. Impaired islet function contributes to the pathogenesis of type 2 diabetes mellitus (T2DM), and targeting inter-organ communications, such as GLP-1 signalling, to enhance β-cell function has been proven to be a successful therapeutic strategy in the last decade. In this review, we will discuss recent advances in inter-organ communication from the metabolic, immune and neural system to pancreatic islets, their biological implication in normal pancreas endocrine function and their role in the (mal)adaptive responses of islet to nutrition-induced stress.

【 授权许可】

Unknown