CircRNAs in gastric cancer: current research and potential clinical implications

FEBS Letters

article

Yixun Lu¹  Kai Li¹  Yunhe Gao²  Wenquan Liang²  Xinxin Wang²  Lin Chen² 

[1] Medical School of Chinese PLA;Department & Institute of General Surgery, the First Medical Center of Chinese PLA General Hospital

关键词: biomarker;    circRNA;    gastric cancer;    ncRNA;    therapeutic target;   

DOI  :  10.1002/1873-3468.14196

来源: John Wiley & Sons Ltd.

【 摘 要 】

Gastric cancer (GC) has a dismal prognosis and is also one of the most commonly diagnosed malignancies worldwide. circRNAs are covalently closed circular RNA molecules without 5′-cap and a 3′-tail, currently listed among the broad noncoding RNA family. circRNAs participate in a variety of pathophysiological processes relevant to human diseases, especially malignancies, including GC. Compelling evidence has shown that circRNAs can function by sponging miRNAs, interacting with RNA binding proteins, and encoding proteins or peptides. Yet, our current understanding of these RNA circles remains very limited. Here, we overview the biogenesis, characteristics, functions, and degradation of circRNAs. Moreover, we give an account of the circRNAs that have been linked with GC, describing their functions and mechanisms of action in the context of GC. Next, we discuss the potential value of circRNAs as diagnostic or prognostic GC biomarkers and summarize future prospects, important questions, and challenges of circRNA-based therapeutics.

【 授权许可】

Unknown