The circadian clock and diseases of the skin

FEBS Letters

article

Junyan Duan¹  Elyse Noelani Greenberg²  Satya Swaroop Karri²  Bogi Andersen¹ 

[1] Center for Complex Biological Systems, University of California;Department of Biological Chemistry, University of California;Department of Medicine, Division of Endocrinology, School of Medicine, University of California;Institute for Genomics and Bioinformatics, University of California

关键词: aging;    cancer;    circadian clock;    circadian medicine;    feeding;    psoriasis;    skin diseases;    stem cells;    stress and immune response;    wound healing;   

DOI  :  10.1002/1873-3468.14192

来源: John Wiley & Sons Ltd.

【 摘 要 】

Organisms have an evolutionarily conserved internal rhythm that helps them anticipate and adapt to daily changes in the environment. Synchronized to the light–dark cycle with a period of around 24 hours, the timing of the circadian clock is set by light-triggering signals sent from the retina to the suprachiasmatic nucleus. Other inputs, including food intake, exercise, and temperature, also affect clocks in peripheral tissues, including skin. Here, we review the intricate interplay between the core clock network and fundamental physiological processes in skin such as homeostasis, regeneration, and immune- and stress responses. We illustrate the effect of feeding time on the skin circadian clock and skin functions, a previously overlooked area of research. We then discuss works that relate the circadian clock and its disruption to skin diseases, including skin cancer, sunburn, hair loss, aging, infections, inflammatory skin diseases, and wound healing. Finally, we highlight the promise of circadian medicine for skin disease prevention and management.

【 授权许可】

Unknown