Endothelial cell autophagy in homeostasis and cancer

FEBS Letters

article

Jelle Verhoeven¹  Jef Baelen¹  Madhur Agrawal¹  Patrizia Agostinis¹ 

[1] Cell Death Research and Therapy Group, Department of Cellular and Molecular Medicine;VIB Center for Cancer Biology Research

关键词: autophagy;    cancer;    endothelial cells;    immunosurveillance;    tumor vasculature;   

DOI  :  10.1002/1873-3468.14087

来源: John Wiley & Sons Ltd.

【 摘 要 】

Autophagy, the major lysosomal pathway for the degradation and recycling of cytoplasmic materials, is increasingly recognized as a major player in endothelial cell (EC) biology and vascular pathology. Particularly in solid tumors, tumor microenvironmental stress such as hypoxia, nutrient deprivation, inflammatory mediators, and metabolic aberrations stimulates autophagy in tumor-associated blood vessels. Increased autophagy in ECs may serve as a mechanism to alleviate stress and restrict exacerbated inflammatory responses. However, increased autophagy in tumor-associated ECs can re-model metabolic pathways and affect the trafficking and surface availability of key mediators and regulators of the interplay between EC and immune cells. In line with this, heightened EC autophagy is involved in pathological angiogenesis, inflammatory, and immune responses. Here, we review major cellular and molecular mechanisms regulated by autophagy in ECs under physiological conditions and discuss recent evidence implicating EC autophagy in tumor angiogenesis and immunosurveillance.

【 授权许可】

Unknown