Elucidating evolutionarily conserved mechanisms of diapause regulation using an in silico approach

FEBS Letters

article

Kamal Ajit¹  Bruce D. Murphy²  Arnab Banerjee¹ 

[1] Department of Biological Sciences, BITS Pilani KK Birla Goa Campus;Centre de Recherche en Reproduction et Fertilité, Faculté de Médicine Vétérinaire, Université Montréal

关键词: computational biology;    embryonic diapause;    evolution;    facultative;    network analysis;    obligate;    pathway analysis;    promoter;    transcription factor;    transcriptome;   

DOI  :  10.1002/1873-3468.14064

来源: John Wiley & Sons Ltd.

【 摘 要 】

Embryonic diapause is an enigmatic phenomenon that appears in diverse species. Although regulatory mechanisms have been established, there is much to be discovered. Herein, we have made the first comprehensive attempt to elucidate diapause regulatory mechanisms using a computational approach. We found transcription factors unique to promoters of genes in diapause species. From pathway analysis and STRING PPI networks, the signaling pathways regulated by these unique transcription factors were identified. The pathways were then consolidated into a model to combine various known mechanisms of diapause regulation. This work also highlighted certain transcription factors that may act as ‘master transcription factors’ to regulate the phenomenon. Promoter analysis further suggested evidence for independent evolution for some of regulatory elements involved in diapause.

【 授权许可】

Unknown