The chromatin modifier MORC2 affects glucose metabolism by regulating the expression of lactate dehydrogenase A through a feed forward loop with c-Myc

FEBS Letters

article

Rohith Kumar Guddeti¹  Liz Thomas¹  Anbarasu Kannan²  Prashanthi Karyala³  Suresh B. Pakala¹ 

[1] Biology Division, Indian Institute of Science Education and Research;Department of Protein Chemistry and Technology, CSIR-Central Food Technological Research Institute;Department of Biochemistry, Indian Academy Degree College Autonomous

关键词: c-Myc;    glucose metabolism;    LDHA;    MORC2;   

DOI  :  10.1002/1873-3468.14062

来源: John Wiley & Sons Ltd.

【 摘 要 】

Microrchidia family CW-type zinc finger 2 (MORC2) is a recently identified chromatin modifier with an emerging role in cancer metastasis. However, its role in glucose metabolism, a hallmark of malignancy, remains to be explored. We found that MORC2 is a glucose-inducible gene and a target of c-Myc. Our meta-analysis revealed that MORC2 expression is positively correlated with the expression of enzymes involved in glucose metabolism in breast cancer patients. Furthermore, overexpression of MORC2 in MCF-7 and BT-549 cells augmented the expression and activity of a key glucose metabolism enzyme, lactate dehydrogenase A (LDHA). Conversely, selective knockdown of MORC2 by siRNA markedly decreased LDHA expression and activity and in turn reduced cancer cell migration. Collectively, these findings provide evidence that MORC2, a glucose-inducible gene, modulates the migration of breast cancer cells through the MORC2–c-Myc–LDHA axis.

【 授权许可】

Unknown