Coding triplets in the tRNA acceptor-TΨC arm and their role in present and past tRNA recognition

FEBS Letters

article

Ilana Agmon¹  Itay Fayerverker³  Tal Mor³ 

[1] Institute for Advanced Studies in Theoretical Chemistry, Schulich Faculty of Chemistry, Technion - Israel Institute of Technology;Fritz Haber Research Center for Molecular Dynamics, Hebrew University Jerusalem;Department of Computer Science

关键词: aminoacylation;    genetic code;    origin of life;    synthetase;    translation;    tRNA;   

DOI  :  10.1002/1873-3468.14044

来源: John Wiley & Sons Ltd.

【 摘 要 】

The mechanism and evolution of the recognition scheme between key components of the translation system, that is, tRNAs, synthetases, and elongation factors, are fundamental issues in understanding the translation of genetic information into proteins. Statistical analysis of bacterial tRNA sequences reveals that for six amino acids, a string of 10 nucleotides preceding the tRNA 3' end carries cognate coding triplets to nearly full extent. The triplets conserved in positions 63–67 are implicated in the recognition by the elongation factor EF-Tu, and those conserved in positions 68–72, in the identification of cognate tRNAs, and their derived minihelices by class IIa synthetases. These coding triplets are suggested to have primordial origin, being engaged in aminoacylation of prebiotic tRNAs and in the establishment of the canonical codon set.

【 授权许可】

Unknown