Therapeutic effects of an oral gonadotropin-releasing hormone receptor antagonist, relugolix, on preventing premature ovulation in mild ovarian stimulation for IVF

Reproductive medicine and biology

article

Akiko Itakura¹  Hideaki Watanabe¹  Satoru Takamizawa¹  Yuko Ojiro¹  Koji Nakagawa¹  Rikikazu Sugiyama¹  Kazuki Nakao¹  Keiji Kuroda¹  Takashi Horikawa¹  Azusa Moriyama¹  Hiroyasu Juen¹ 

[1]Center for Reproductive Medicine and Implantation Research, Sugiyama Clinic Shinjuku

[2]Department of Obstetrics and Gynecology, Faculty of Medicine, Juntendo University

关键词: Gonadotropin-releasing hormone receptor antagonist;    in vitro fertilization;    mild ovarian stimulation;    premature ovulation;    relugolix;   

DOI  :  10.1002/rmb2.12422

学科分类：工业工程学

来源: Wiley

【 摘 要 】

Purpose Can relugolix, a novel oral gonadotropin-releasing hormone receptor (GnRH) antagonist, function as an alternative ovulation inhibitor to GnRH antagonist injections? Methods This single-center, cross-sectional retrospective study compared premature ovulation rates and clinical outcomes in IVF treatment after mild ovarian stimulation with 40 mg of relugolix (relugolix group) or 0.25-mg injections of ganirelix acetate or cetrorelix acetate (injection group) between March 2019 and January 2020. Of 247 infertile women (256 IVF cycles) aged ≤42 years, 223 women (230 cycles) were evaluated. In the relugolix and injection groups, we compared 104 and 85 cycles after GnRH antagonist use before the LH surge (LH levels <10 mIU/ml) and 22 and 19 cycles during the LH surge (LH levels ≥10 mIU/ml), respectively. Results Before the LH surge, the ovulation rates in the two groups were very low ( p  = 0.838), however; during the LH surge, the cycles using relugolix had a high ovulation rate of 40.9% compared with no ovulation in the injection group ( p  = 0.002). There were no significant differences in embryo culture findings and pregnancy outcomes between the two groups. Conclusions Although relugolix had a high ovulation suppressive effect, when the LH surge occurred, its effect was insufficient.

【 授权许可】

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