Effects of antioxidant co-supplementation therapy on spermatogenesis dysfunction in relation to the basal oxidation–reduction potential levels in spermatozoa: A pilot study

Reproductive medicine and biology

article

Kazumitsu Yamasaki¹  Masahiro Uchida¹  Noriko Watanabe³  Tatsuji Ihana⁴  Yukari Ishiguro⁵  Shinnosuke Kuroda⁵  Teppei Takeshima⁵  Yasushi Yumura⁵  Makiko Mieno⁶  Kaoru Yoshida⁷  Teruaki Iwamoto²  Hiroyuki Nishiyama⁸ 

[1] Department of Urology, Tsukuba Gakuen Hospital;Male Infertility Center for Human Reproduction, Sanno Hospital;Oak Clinic Ginza;Center for Human Reproduction and Gynecologic Endoscopy, Sanno Hospital;Department of Urology, Reproduction Center, Yokohama City University Medical Center;Department of Medical Informatics, Center for Information, Jichi Medical University;Faculty of Biomedical Engineering, Toin University of Yokohama;Department of Urology, Faculty of Medicine, University of Tsukuba

关键词: 8-hydroxy-2′-deoxyguanosine;    antioxidant;    infertility;    male;    oxidation–reduction;    sperm count;   

DOI  :  10.1002/rmb2.12450

学科分类：工业工程学

来源: Wiley

【 摘 要 】

Purpose In this pilot study, the authors compared the effects of antioxidant co-supplementation therapy and methylcobalamin therapy in patients with impaired semen quality. Methods Eighty-four subjects who visited male infertility clinics and showed abnormal semen test results were randomly subjected to one of the two therapies: antioxidant co-supplementation therapy with vitamin C, vitamin E, coenzyme Q10, and flaxseed oil or methylcobalamin therapy. The oxidation–reduction potential (ORP) and 8-hydroxy-2′-deoxyguanosine levels were used as indicators of oxidative stress levels in semen. Semen analysis was also performed. Results The authors obtained results from 67 patients who had completed 3 months of treatment. Neither antioxidant co-supplementation therapy nor methylcobalamin therapy changed the semen parameters significantly (except for the sperm concentration, which was increased by the latter therapy). When the pre-treatment ORP value in semen was higher than the cutoff value, both therapies significantly increased the sperm concentration. The 8-hydroxy-2′-deoxyguanosine level did not yield any meaningful predictive value with regard to increased sperm concentrations. Conclusions Both antioxidant co-supplementation therapy and methylcobalamin therapy increased the sperm concentration in patients with impaired semen quality when the basal ORP levels in their semen were elevated.

【 授权许可】

CC BY|CC BY-NC|CC BY-NC-ND