Molecular basis of the morphogenesis of sperm head and tail in mice

Reproductive medicine and biology

article

Keiichiro Yogo¹ 

[1] Department of Applied Life Sciences, Faculty of Agriculture, Shizuoka University

关键词: acrosome;    axoneme;    flagellum;    mouse;    spermatogenesis;   

DOI  :  10.1002/rmb2.12466

学科分类：工业工程学

来源: Wiley

【 摘 要 】

Background The spermatozoon has a complex molecular apparatus necessary for fertilization in its head and flagellum. Recently, numerous genes that are needed to construct the molecular apparatus of spermatozoa have been identified through the analysis of genetically modified mice. Methods Based on the literature information, the molecular basis of the morphogenesis of sperm heads and flagella in mice was summarized. Main findings (Results) The molecular mechanisms of vesicular trafficking and intraflagellar transport in acrosome and flagellum formation were listed. With the development of cryo-electron tomography and mass spectrometry techniques, the details of the axonemal structure are becoming clearer. The fine structure and the proteins needed to form the central apparatus, outer and inner dynein arms, nexin-dynein regulatory complex, and radial spokes were described. The important components of the formation of the mitochondrial sheath, fibrous sheath, outer dense fiber, and the annulus were also described. The similarities and differences between sperm flagella and Chlamydomonas flagella/somatic cell cilia were also discussed. Conclusion The molecular mechanism of formation of the sperm head and flagellum has been clarified using the mouse as a model. These studies will help to better understand the diversity of sperm morphology and the causes of male infertility.

【 授权许可】

CC BY|CC BY-NC|CC BY-NC-ND