Aspiration of excess follicles before intrauterine insemination in high response cycles

Reproductive medicine and biology

article

Begoña Prieto¹  Maria Diaz-Nuñez¹  Lucia Lainz¹  Alberto Vendrell³  Aintzane Rabanal¹  Maria Iglesias¹  Teresa Jauregui¹  Beatriz Corcostegui¹  Ana Matorras⁵  Silvia Perez³  Roberto Matorras¹ 

[1] Human Reproduction Unit, Cruces University Hospital;Faculty of Medicine, University of the Basque Country;Biocruces Bizkaia Health Research Institute;Instituto Valenciano de Infertilidad;European University of Madrid

关键词: follicular aspiration;    hyperresponse;    intrauterine insemination;    multiple pregnancy;    pregnancy rate;   

DOI  :  10.1002/rmb2.12470

学科分类：工业工程学

来源: Wiley

【 摘 要 】

Purpose To assess the outcome of excess follicle aspiration before intrauterine insemination (EFABI) in intrauterine insemination (IUI) cycles with 4–6 follicles ≥14 mm. Methods A retrospective case–control study with 1559 patients undergoing IUI (donor and husband's sperm), of whom 86 underwent EFABI. We studied also an historical series of 2213 patients before EFABI implementation. For 3.5 years, all women undergoing IUI developing 4–6 follicles ≥14 mm were offered EFABI on the day of hCG administration. Pregnancy rates (PRs), multiple PRs, and adverse effects were measured. Results EFABI was associated with a similar multiple PR (17.8% vs 17.5% in non-EFABI cases), with no triplets in EFABI patients. Live birth rates were significantly higher in EFABI cycles in IUI overall (25.5% vs 15.2%). When considered separately, the performance of EFABI resulted in significantly increased live birth rates in IUI-donor cycles (32.5% vs 18.5%), whereas the differences in IUI-husband cycles (19.5% vs 12.9%) did not reach statistical significance. The PR was 21.2% during the EFABI implementation period and 19.4% in the pre-EFABI period. Conclusions EFABI in cycles in which 4–6 follicles reach ≥14 mm is a simple option that reduces cycle cancellation rates, results in higher PRs than cycles with 1–3 follicles, and lowers the risk of multiple pregnancy.

【 授权许可】

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