Periconception and Prenatal Exposure to Maternal Perceived Stress and Cord Blood DNA Methylation

Epigenetics Insights

article

Kristen J Polinski¹  Diane L Putnick¹  Sonia L Robinson¹  Karen C Schliep²  Robert M Silver²  Weihua Guan³  Enrique F Schisterman⁴  Sunni L Mumford⁴  Edwina H Yeung¹ 

[1] Division of Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health;Department of Family and Preventive Medicine, University of Utah;Division of Biostatistics, University of Minnesota;Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania

关键词: DNA methylation;    epidemiology;    perceived stress;    periconception;   

DOI  :  10.1177/25168657221082045

学科分类：兽医学

来源: Tu Delft Transport Institute

【 摘 要 】

Background: Maternal prenatal stress is associated with physiologic and adverse mental health outcomes in the offspring, but the underlying biologic mechanisms are unknown. We examined the associations of maternal perceived stress, including preconception exposure, with DNA methylation (DNAm) alterations in the cord blood buffy coats of 358 singleton infants.

【 授权许可】

CC BY|CC BY-NC