Stress Overload and DNA Methylation in African American Women in the Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure Study

Epigenetics Insights

article

Jolaade Kalinowski¹  Yunfeng Huang²  Martin A Rivas³  Veronica Barcelona⁴  Michelle L Wright⁵  Cindy Crusto⁶  Tanya Spruill⁷  Yan V Sun²  Jacquelyn Y Taylor⁴ 

[1] Department of Human Development and Family Sciences, The University of Connecticut;Rollins School of Public Health, Emory University;Department of Medicine, Weill Cornell Medicine;Columbia University School of Nursing and Center for Research on People of Color;University of Texas at Austin School of Nursing;Yale School of Medicine;Department of Population Health, NYU Grossman School of Medicine

关键词: DNA methylation;    stress;    cardiovascular disease;    African American;    EWAS;    women’s health;   

DOI  :  10.1177/25168657221126314

学科分类：兽医学

来源: Tu Delft Transport Institute

【 摘 要 】

Introduction: Experiencing psychosocial stress is associated with poor health outcomes such as hypertension and obesity, which are risk factors for developing cardiovascular disease. African American women experience disproportionate risk for cardiovascular disease including exposure to high levels of psychosocial stress. We hypothesized that psychosocial stress, such as perceived stress overload, may influence epigenetic marks, specifically DNA methylation (DNAm), that contribute to increased risk for cardiovascular disease in African American women.

【 授权许可】

CC BY|CC BY-NC