Nanotechnology-based formulations to amplify intraocular bioavailability

Therapeutic Advances in Ophthalmology

article

Philipp Anders¹  Lisa-Marie Anders¹  Adel Barbara³  Nora Szentmary⁴  Achim Langenbucher⁵  Zisis Gatzioufas¹ 

[1] Institute of Molecular and Clinical Ophthalmology Basel;Department of Ophthalmology, University of Basel;IVISION Laser Refractive Center;Dr. Rolf M. Schwiete Center for Limbal Stem Cell and Congenital Aniridia Research, Saarland University;Experimental Ophthalmology, Saarland University

关键词: cataract;    cataract extraction;    corneal surgery;    excimer laser;    IOL power;    IOL power miscalculation;    keratometry;    LASIK;    PRK;    refractive surgery;    RK;    SMILE;   

DOI  :  10.1177/25158414221118524

学科分类：社会科学、人文和艺术（综合）

来源: Gdansk University Of Physical Education And Sport

【 摘 要 】

Intraocular lens (IOL) power calculation after corneal refractive surgery (CRS) becomes an expanding challenge for ophthalmologists as more and more cataract surgeries after CRS are required. These patients typically also have high expectations as to visual performance. Conventional IOL power calculation schemes frequently provide inaccurate results in these cases. This review aims to summarize and recommend currently available IOL power calculation methods for eyes with the most common CRS methods: radial keratotomy (RK), photorefractive keratectomy (PRK), laser in situ keratomileusis (LASIK), and small incision lenticule extraction (SMILE). To this end, biometry measuring methods and IOL formulas will be explained and combinations of both are proposed. In synopsis, it is evident that the latest generation of vergence formulas exhibit favorable IOL power prediction accuracy in post-CRS eyes, even though the predictive precision of methods in eyes without CRS is not attained. Ray tracing computation, intraoperative aberrometry, and machine learning–based formulas hold potential to further improve refractive outcomes in post-CRS eyes.

【 授权许可】

CC BY|CC BY-NC