Therapeutic Advances in Ophthalmology | |
Changes in ocular pulse amplitude and posterior ocular structure parameters in type 1 diabetic children without diabetic retinopathy | |
article | |
Abdulvahit Asik1  Semih Bolu2  Ilke Direkci3  Emre Aydemir3  Gozde Aksoy Aydemir3  | |
[1] Department of Pediatrics, Adıyaman University Education and Research Hospital;Department of Pediatric Endocrinology, Adıyaman University Education and Research Hospital;Ophthalmology Department, Adıyaman University Education and Research Hospital | |
关键词: choroidal blood flow; choroidal thickness; dynamic contour tonometry; EDI mode OCT; ocular pulse amplitude; type 1 diabetes mellitus; | |
DOI : 10.1177/25158414221101710 | |
学科分类:社会科学、人文和艺术(综合) | |
来源: Gdansk University Of Physical Education And Sport | |
【 摘 要 】
Background: It is important to determine changes in posterior ocular structures in the earlyperiod before retinopathy develops in pediatric patients with type 1 diabetes mellitus (DM).Objective: To evaluate inner plexiform layer (IPL), ganglion cell layer (GCL), and retinal nervefiber layer (RNFL) thicknesses, as well as the relationship between choroidal thickness (CT)and ocular pulse amplitude (OPA) in type 1 diabetic children without diabetic retinopathy (DR).Design: A prospective observational study.Methods: Group 1 (n=44) consisted of pediatric patients with type 1 DM without DR, andGroup 2 (n=65) of pediatric control subjects. Both intraocular pressure (IOP) and OPA weremeasured using a dynamic contour tonometer. CT, IPL, GCL, and RNFL were all measuredusing spectral domain optical coherence tomography (OCT).Results: The mean IOP and OPA values were 16.67±2.34 and 1.85±0.34, respectively, ingroup 1, and 15.14±2.17 and 1.65±0.25 in Group 2 (p=0.001 for both). The mean subfovealCT value was 294.30±67.61μm in group 1 and 394.42±69.65μm in Group 2 (p<0.001). Themean GCL and RNFL values were 1.09±0.11 and 96.46±11.69, respectively, in group 1, and1.14±0.09 and 101.73±9.33 in Group 2 (p=0.005 and p=0.008, respectively).Conclusions: IOP and OPA values were higher, and CT, GCL, and RNFL values were lowerin children with type 1 DM during the early stages than in the healthy control group. Thesefindings suggest that CT may be a marker of retinal involvement in children with type 1 DMwithout DR.
【 授权许可】
CC BY|CC BY-NC
【 预 览 】
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