A comprehensive review of intravitreal immunosuppressants and biologicals used in ophthalmology

Therapeutic Advances in Ophthalmology

article

Farshad Askarizadeh¹  Mohsen Heirani²  Masoud Khorrami-Nejad²  Foroozan Narooie-Noori³  Mehdi Khabazkhoob⁴  Alireza Ostadrahimi⁵ 

[1] Department of Optometry, Faculty of Rehabilitation Sciences, Tabriz University of Medical Sciences;Translational Ophthalmology Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences;Department of Optometry, Faculty of Rehabilitation Sciences, Iran University of Medical Sciences;Department of Medical Surgical Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, IranNoor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital;Nutrition Research Center, Tabriz University of Medical Sciences

关键词: body mass index;    choroidal thickness;    enhanced depth imaging;    obesity;    optical coherence tomography;   

DOI  :  10.1177/25158414221100649

学科分类：社会科学、人文和艺术（综合）

来源: Gdansk University Of Physical Education And Sport

【 摘 要 】

Obesity is a health-threatening and epidemic medical condition that can affect individuals of different ages and is potentially associated with an increased risk of systemic and ocular disorders. Despite the well-documented adverse effects of obesity on different parts of the body vasculature, less published data are available concerning obesity-related consequences on the ocular vasculature. As the human choroid is a highly vascularized tissue, its morphology and function might be altered in obese individuals. The micro-structural changes within the choroid could also trigger development of subsequent functional abnormalities of the eye. Previous population-based studies have asserted an association between obesity and choroidal thickness; however, they reported conflicting patterns of association between obesity and changes in choroidal thickness. Therefore, to enhance our understanding of the changes in choroidal morphology secondary to obesity, we reviewed studies describing the micro-structural consequences of obesity on the choroidal thickness profile and its underlying physiological and anatomical basis. This review includes all original publications related to the association between choroidal thickness and obesity published until mid-2021 that were indexed in PubMed, Google Scholar, ScienceDirect, or Scopus.

【 授权许可】

CC BY|CC BY-NC