Prophylactic and Therapeutic Effect of Kynurenine for Experimental Autoimmune Encephalomyelitis (EAE) Disease

International Journal of Tryptophan Research

article

Gayathri Sundaram¹  Alban Bessede³  David Gilot⁴  Ananda Staats Pires⁵  Larry S Sherman⁷  Bruce J Brew¹  Gilles J Guillemin¹ 

[1] Peter Duncan Neurosciences Research Unit, St Vincent’s Centre for Applied Medical Research;St Vincent’s Clinical School, Faculty of Medicine, University of New South Wales;ImmuSmol;INSERM U1242, University of Rennes I;Neuroinflammation Group, Faculty of Medicine, Health and Human Sciences, Macquarie University;Laboratório de Bioenergética e Estresse Oxidativo, Departamento de Bioquímica, Universidade Federal de Santa Catarina;Division of Neuroscience, Oregon National Primate Research Center;Department of Cell, Developmental, and Cancer Biology, Oregon Health & Science University;Department of Neurology, St Vincent’s Hospital;University of Notre Dame

关键词: Tryptophan;    kynurenine;    kynurenine pathway;    aryl-hydrocarbon receptor;    ligand;    pro-ligand;    multiple sclerosis;    immunosuppression;   

DOI  :  10.1177/11786469221118657

学科分类：生理学与病理学

来源: Sage Journals

【 摘 要 】

Background: The essential amino acid, tryptophan, is predominantly metabolised through the kynurenine pathway (KP) to generate kynurenine, an aryl-hydrocarbon receptor (AhR) pro-ligand that exerts its effects in a ligand-dependent manner. Interaction between kynurenine and the AhR is an effector mechanism of immunosuppression. We previously found that the KP is involved in multiple sclerosis (MS) disease progression. We postulated that AhR activation by kynurenine might be neuroprotective by encouraging differentiation of Tregs. In this study, we assess both the prophylactic and therapeutic efficiency of kynurenine on disease severity and progression in mice with experimental autoimmune encephalomyelitis (EAE), an MS model.

【 授权许可】

CC BY|CC BY-NC