Solitary Fibrous Tumors of the Head and Neck: A Single-Institution Study of 52 Patients

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Colin MacKay¹  Brooke Turner¹  Martin Bullock²  S. Mark Taylor¹  Jonathan Trites¹  Martin Corsten¹  Laurette Geldenhuys²  Matthew H. Rigby¹ 

[1] Division of Otolaryngology–Head and Neck Surgery, Department of Surgery, Queen Elizabeth II Health Science Centre and Dalhousie University;Division of Anatomical Pathology, Department of Pathology, Queen Elizabeth II Health Science Centre and Dalhousie University

关键词: specimen oriented;    survival outcomes;    oral cavity;    oropharynx;    squamous cell carcinoma;   

DOI  :  10.1177/2473974X221101024

学科分类：社会科学、人文和艺术（综合）

来源: Sage Journals

【 摘 要 】

Objective. To compare the association of margin samplingtechnique on survival outcomes in surgically treated cT1-2oral cavity and oropharyngeal squamous cell carcinoma.Study Design. A prospective longitudinal cohort study.Setting. Tertiary care academic teaching hospital in Halifax, NovaScotia.Methods. All cases of surgically treated cT1-2 oral cavity andoropharyngeal cancer undergoing specimen-oriented marginanalysis between January 1, 2017, and December 31, 2018were analyzed. The specimen-oriented cohort was compared with a cohort of patients from January 1, 2009, toDecember 31, 2014, where a defect-oriented margin sampling protocol was used. Kaplan-Meier survival curves wereused to estimate 2-year overall survival, disease-specific survival, local control, and recurrence-free survival rates in oralcavity and p16-positive oropharyngeal squamous cell carcinoma. Cox proportional hazards models were used toassess the effect of margin sampling method on diseasespecific survival and local control.Results. There was no significant association between marginsampling technique and 2-year survival outcomes for surgically treated cT1-2 oral cavity and oropharyngeal squamouscell carcinoma. In the multivariate Cox proportional hazardmodel, the hazard ratio (HR) of specimen-oriented samplingwas not significantly different for disease-specific survival(HR, 1.32; 95% CI, 0.3032-5.727; P = .713) or local control(HR, 0.4087; 95% CI, 0.0795-2.099; P = .284).Conclusion. Intraoperative margin sampling method was notassociated with a significant change in 2-year survival outcomes. Despite no effect on survival outcomes, implementation of a specimen-oriented sampling method has potentialfor cost avoidance by decreasing the number of re-resectionsfor positive or close margins.

【 授权许可】

CC BY|CC BY-NC