Life events and psychosis: case–control study from India, Nigeria, and Trinidad and Tobago

BJPsych Open

article

Ibidunni O. Oloniniyi¹  Helen A. Weiss²  Sujit John³  Oluyomi Esan⁴  Maia Hibben⁵  Vikram Patel⁶  Robin M. Murray⁸  Alex Cohen⁹  Gerard Hutchinson⁵  Oye Gureje^1,10  Rangaswamy Thara³  Craig Morgan^1,11  Tessa Roberts^1,11 

[1] Department of Health Services and Population Research, Institute of Psychiatry, Psychology and Neuroscience, King's College London;MRC International Statistics and Epidemiology Group, London School of Hygiene & Tropical Medicine;Department of Psychiatry, Schizophrenia Research Foundation;Department of Psychiatry, University of Ibadan;Department of Psychiatry, Faculty of Medical Sciences, University of the West Indies;Department of Global Health and Social Medicine, Harvard Medical School;and Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Harvard University;Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London;Centre for Global Mental Health, London School of Hygiene & Tropical Medicine;WHO Collaborating Centre for Research and Training in Mental Health, Neuroscience and Substance Abuse, Department of Psychiatry, University of Ibadan;ESRC Centre for Society and Mental Health, King's College London

关键词: Psychosis;    life events;    India;    Nigeria;    Trinidad and Tobago;   

DOI  :  10.1192/bjo.2022.562

学科分类：计算机科学（综合）

来源: Canadian Society For Pharmaceutical Sciences (Csps).

【 摘 要 】

Background There is evidence of an association between life events andpsychosis in Europe, North America and Australasia, but fewstudies have examined this association in the rest of the world.AimsTo test the association between exposure to life events andpsychosis in catchment areas in India, Nigeria, and Trinidad andTobago.MethodWe conducted a population-based, matched case–control studyof 194 participants in India, Nigeria, and Trinidad and Tobago.Cases were recruited through comprehensive population-based,case-finding strategies. The Harvard Trauma Questionnaire wasused to measure life events. The Screening Schedule forPsychosis was used to screen for psychotic symptoms. Theassociation between psychosis and having experienced lifeevents (experienced or witnessed) was estimated by conditionallogistic regression.ResultsThere was no overall evidence of an association betweenpsychosis and having experienced or witnessed life events(adjusted odds ratio 1.19, 95% CI 0.62–2.28). We found evidenceof effect modification by site (P = 0.002), with stronger evidenceof an association in India (adjusted odds ratio 1.56, 95% CI 1.03–2.34), inconclusive evidence in Nigeria (adjusted odds ratio 1.17,95% CI 0.95–1.45) and evidence of an inverse association inTrinidad and Tobago (adjusted odds ratio 0.66, 95% CI 0.44–0.97).ConclusionsThis study found no overall evidence of an association betweenwitnessing or experiencing life events and psychotic disorderacross three culturally and economically diverse countries.There was preliminary evidence that the association variesbetween settings.

【 授权许可】

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