Cariprazine as a treatment for negative psychotic symptoms in first-episode psychosis: case series

BJPsych Open

article

Pradeep Peddu¹  Philip McGuire²  Arsime Demjaha²  Eduardo Iacoponi⁴  Lars Hansen⁵ 

[1] Psychosis Service;Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London;and NIHR Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust and King's College London;Lambeth Early Intervention Service, South London and Maudsley NHS Foundation Trust;Department of Psychiatry, Southampton University

关键词: Negative symptoms;    cariprazine;    first-episode psychosis;    antipsychotics;    novel central nervous system drugs;   

DOI  :  10.1192/bjo.2022.56

学科分类：计算机科学（综合）

来源: Canadian Society For Pharmaceutical Sciences (Csps).

【 摘 要 】

Negative psychotic symptoms are among the most disabling features of schizophrenia, and are strongly associated with relatively poor clinical and functional outcomes. However, there are no effective treatments for negative symptoms, and this represents a major unmet clinical need. Recent research has shown that negative symptoms are already present in many patients at illness onset. There is evidence that cariprazine may improve negative symptoms in patients with chronic schizophrenia. However, its utility in treating negative symptoms in the early stage of the disorder is unclear. Here, we report six cases of patients with first-episode psychosis who were treated with cariprazine.

【 授权许可】

CC BY|CC BY-NC-SA|CC BY-NC-ND