Lymphatic Filariasis: An Immunologic Perspective

European Medical Journal Allergy & Immunology

article

Joshua Angelo Hermida Mandanas¹ 

[1] University of Perpetual Help, Dr. Jose G. Tamayo Medical University Santo Niňo

关键词: Brugia malayi;    helminth;    immunology;    lymphatic filariasis;    Wuchereria bancrofti.;   

DOI  :  10.33590/emjallergyimmunol/20-00252

学科分类：社会科学、人文和艺术（综合）

来源: European Medical Journal

【 摘 要 】

Introduction: This paper provides an overview of the current immunologic research findings of lymphatic filarial worms, which affect millions of people worldwide. Objectives: This paper aims to discuss the immunologic features of lymphatic filarial worms. It also aims to highlight their potential anti-inflammatory actions and the use of anti-filarial drugs against COVID-19. Methods: A literature review was performed to obtain insights on the immunologic features of lymphatic filarial worms. Results: The CD4+ (Th2) response profile is the main defence against filarial worms. Modulation of human immune responses are primarily mediated by parasite-secreted peptides. Lymphatic filarial worms have anti-inflammatory potentials. Drug repurposing of diethylcarbamazepine, doxycycline, and ivermectin can be looked upon against COVID-19. Conclusion: Lymphatic filarial worms have several immunologic effects on host immune systems, which promote chronic infection and curtail anti-inflammatory responses. Insights in this paper can serve as a guide for the understanding of immunologic aspects of lymphatic filarial worms.

【 授权许可】

CC BY-NC