Optimised Tumour Sampling and Processing by a Multidisciplinary Approach for an Accurate Diagnosis in Non-Small Cell Lung Cancer

European Medical Journal Oncology

article

Giulio Rossi¹  Irene Bargellini²  Martina Bonifazi³  Pierpaolo Camplese⁵  Piero Candoli⁶  Loris Ceron⁷  Stefano Gasparini³  Pier Luigi Granone⁸  Francesco Grossi⁹  Roberto Iezzi^1,10  Antonio Marchetti^1,11  Michela Maur^1,12  Venerino Poletti^1,13  Alessandro Posa^1,15  Rocco Trisolini^1,16  Andrea Veltri^1,17  Federica Zito-Marino^1,18 

[1] Operative Units of Pathology, S. Maria delle Croci Hospital of Ravenna and Degli Infermi Hospital of Rimini;Department of Interventional Radiology, Pisa University Hospital;Department of Biomedical Sciences and Public Health, Polytechnic University of Marche;Pulmonary Diseases Unit, Department of Internal Medicine;Thoracic Surgery Unit, D’Annunzio University of Chieti-Pescara University Hospital “SS. Annunziata”;Pulmonology Unit, Pesaro Fano Hospitals;Pulmonology Unit, Ospedale dell’Angelo;Department of General Thoracic Surgery, Catholic University;Division of Medical Oncology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico;Department of Bioimaging, Institute of Radiology, “A. Gemelli” Hospital, Catholic University of the Sacred Heart;Center of Predictive Molecular Medicine, CeSI-MeT, University of Chieti-Pescara;Division of Medical Oncology, Department of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena;Department of Diseases of the Thorax, Ospedale GB Morgagni;Department of Respiratory Diseases & Allergy, Aarhus University Hospital;Department of Radiology, S. Giovanni Calibita Fatebenefratelli Hospital;Interventional Pulmonology Unit, S. Orsola-Malpighi Hospital and Maggiore Hospital;Radiology Unit, Department of Oncology. A.O.U. San Luigi Gonzaga;Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, Università degli Studi della Campania “Luigi Vanvitelli”

关键词: Cell-block;    cytology;    fine needle aspiration (FNA);    histology;    immunohistochemistry;    next-generation sequencing (NGS);    non-small cell lung cancer (NSCLC);    tissue;   

DOI  :  10.33590/emjoncol/10311320

学科分类：社会科学、人文和艺术（综合）

来源: European Medical Journal

【 摘 要 】

The classification of lung cancer has evolved parallel to the knowledge of its biomolecular features and is implemented by the analysis of specific gene alterations, which have shown prognostic and predictive values. Consequently, the diagnosis of a specific ‘biomolecular subtype’ of lung cancer is accompanied by different therapeutic strategies. Optimal target tissue sampling plays a key role in the diagnosis and treatment of lung cancer. Tissue samples can be obtained through various techniques involving different healthcare professionals. Therefore, a multidisciplinary approach is crucial to obtain a suitable diagnostic sample encompassing as much of the information as possible for optimal therapeutic management. In this paper, the authors share the expertise of all professionals involved in the diagnostic and therapeutic approaches of patients with lung cancer: pulmonologists, pathologists, oncologists, radiologists, surgeons, and molecular biologists. The different know-how contributions have been gathered in a single text to offer a comprehensive view on the management of the lung cancer tissue journey.

【 授权许可】

CC BY-NC