Alcohol Consumption and Risk of Atrial Fibrillation: A Dose-Response Meta-Analysis of Prospective Studies

Frontiers in Cardiovascular Medicine

article

Qi-Yu Wang¹  Yi-Han Wang²  Ze-Zhong Cao²  Lu-Lu Chen³  Jin-Yu Sun²  Mu-Feng Gu³  Heng-Zhi Zhang²  Bo Shao² 

[1] School of Mathematical Science, University of Nottingham;Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University;Department of Anatomy, Histology, and Embryology, Nanjing Medical University

关键词: alcohol;    alcohol consumption;    atrial fibrillation;    meta-analysis;    low alcohol intake;   

DOI  :  10.3389/fcvm.2022.802163

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Background This study aimed to investigate the dose-response association between alcohol consumption and atrial fibrillation (AF) risk. Methods PubMed, Embase, Cochrane Library, and Web of Science were systematically searched using keywords related to alcohol and AF from the establishment of databases up to 1 March 2021. Prospective studies examining the impact of alcohol on the risk of AF with hazard ratios (HRs) were included. Restricted cubic spline regression was performed to quantify the dose-response relationship between alcohol consumption and AF risk. Results Thirteen eligible studies were included in the meta-analysis, with a total of 645,826 participants and 23,079 cases of AF. When compared with non-/seldom-drinkers, the pooled adjusted HRs of AF were 1.30 (95% confidence interval [CI]: 1.20–1.41) and 1.00 (95% CI: 0.96–1.05) for high and low alcohol consumption, respectively. Moderate alcohol intake significantly increased the risk of AF in males (HR, 1.21; 95% CI: 1.10–1.33) but not in females (HR, 1.02; 95% CI: 0.91–1.14). The cubic spline regression analysis illustrated that the risk of AF significantly increased with daily alcohol intake in a Non-linear manner (R 2 = 0.64, P = 5.785 × 10 −12 ). Conclusion This study revealed a Non-linearly positive association between alcohol intake and the risk of AF. Low alcohol intake was not associated with the development of AF, whereas moderate alcohol intake significantly increased the risk of AF in males but not in females. Our meta-analysis highlighted that alcohol consumption should be restricted to a low level to reduce the risk of AF.

【 授权许可】

CC BY