Cardioprotective Effects and Possible Mechanisms of Luteolin for Myocardial Ischemia-Reperfusion Injury: A Systematic Review and Meta-Analysis of Preclinical Evidence

Frontiers in Cardiovascular Medicine

article

Qinyuan Pan¹  Yang Liu¹  Wenrui Ma¹  Rongsheng Kan²  Hong Zhu²  Dongye Li¹ 

[1] Institute of Cardiovascular Disease Research, Xuzhou Medical University;Department of Cardiology, The Affiliated Hospital of Xuzhou Medical University

关键词: luteolin;    myocardial ischemia-reperfusion injury;    apoptosis;    oxidation;    inflammation;   

DOI  :  10.3389/fcvm.2022.685998

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Background At present, effective clinical therapies for myocardial ischemia-reperfusion injury (MIRI) are lacking. We investigated if luteolin conferred cardioprotective effects against MIRI and elucidated the potential underlying mechanisms. Method Four databases were searched for preclinical studies of luteolin for the treatment of MIRI. The primary outcomes were myocardial infarct size (IS) and intracardiac hemodynamics. The second outcomes were representative indicators of apoptosis, oxidative stress, and inflammatory. The Stata and RevMan software packages were utilized for data analysis. Results Luteolin administration was confirmed to reduce IS and ameliorate hemodynamics as compared to the control groups ( p < 0.01). IS had decreased by 2.50%, 2.14%, 2.54% in three subgroups. Amelioration of hemodynamics was apparent in two different myocardial infarct models (model of left anterior descending branch ligation and model of global heart ischemia), as left ventricular systolic pressure improved by 21.62 and 35.40 mmHg respectively, left ventricular end-diastolic pressure decreased by 7.79 and 4.73 mmHg respectively, maximum rate of left ventricular pressure rise increased by 737.48 and 750.47 mmHg/s respectively, and maximum rate of left ventricular pressure decrease increased by 605.66 and 790.64 mmHg/s respectively. Apoptosis of cardiomyocytes also significantly decreased, as indicated by thelevels of MDA, an oxidative stress product, and expression of the inflammatory factor TNF-α ( p < 0.001). Conclusion Pooling of the data demonstrated that luteolin exerts cardioprotective effects against MIRI through different signaling pathways. As possible mechanisms, luteolin exerts anti-apoptosis, anti-oxidation, and anti-inflammation effects against MIRI.

【 授权许可】

CC BY