Evidence for the Benefits of Melatonin in Cardiovascular Disease

Frontiers in Cardiovascular Medicine

article

Mohammad Tobeiha¹  Ameneh Jafari³  Sara Fadaei⁵  Seyed Mohammad Ali Mirazimi¹  Fatemeh Dashti¹  Atefeh Amiri⁶  Haroon Khan⁷  Zatollah Asemi⁸  Russel J. Reiter⁹  Michael R. Hamblin^1,10  Hamed Mirzaei⁸ 

[1] School of Medicine, Kashan University of Medical Sciences;Student Research Committee, Kashan University of Medical Sciences;Advanced Therapy Medicinal Product ,(ATMP) Department, Breast Cancer Research Center, Motamed Cancer Institute;Proteomics Research Center, Shahid Beheshti University of Medical Sciences;Department of Internal Medicine and Endocrinology, Beheshti University of Medical Sciences;Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences;Department of Pharmacy, Abdul Wali Khan University;Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences;Department of Cell Systems and Anatomy, UT Health. Long School of Medicine;Laser Research Centre, Faculty of Health Science, University of Johannesburg

关键词: cardiovascular disease;    pathophysiology;    melatonin;    antioxidant;    cardiotoxicity;   

DOI  :  10.3389/fcvm.2022.888319

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

The pineal gland is a neuroendocrine gland which produces melatonin, a neuroendocrine hormone with critical physiological roles in the circadian rhythm and sleep-wake cycle. Melatonin has been shown to possess anti-oxidant activity and neuroprotective properties. Numerous studies have shown that melatonin has significant functions in cardiovascular disease, and may have anti-aging properties. The ability of melatonin to decrease primary hypertension needs to be more extensively evaluated. Melatonin has shown significant benefits in reducing cardiac pathology, and preventing the death of cardiac muscle in response to ischemia-reperfusion in rodent species. Moreover, melatonin may also prevent the hypertrophy of the heart muscle under some circumstances, which in turn would lessen the development of heart failure. Several currently used conventional drugs show cardiotoxicity as an adverse effect. Recent rodent studies have shown that melatonin acts as an anti-oxidant and is effective in suppressing heart damage mediated by pharmacologic drugs. Therefore, melatonin has been shown to have cardioprotective activity in multiple animal and human studies. Herein, we summarize the most established benefits of melatonin in the cardiovascular system with a focus on the molecular mechanisms of action.

【 授权许可】

CC BY