Role and Mechanism of PKC-δ for Cardiovascular Disease: Current Status and Perspective

Frontiers in Cardiovascular Medicine

article

Li-na Miao¹  Deng Pan¹  Junhe Shi¹  Jian-peng Du¹  Peng-fei Chen¹  Jie Gao¹  Yanqiao Yu¹  Da-Zhuo Shi¹  Ming Guo¹ 

[1] Xiyuan Hospital, China Academy of Chinese Medical Sciences;Department of Graduate School, Beijing University of Chinese Medicine;China Heart Institute of Chinese Medicine, China Academy of Chinese Medical Sciences

关键词: cardiovascular disease;    PKC-δ;    kinase;    mechanism;    PKC;   

DOI  :  10.3389/fcvm.2022.816369

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Protein kinase C (PKC) is a protein kinase with important cellular functions. PKC-δ, a member of the novel PKC subfamily, has been well-documented over the years. Activation of PKC-δ plays an important regulatory role in myocardial ischemia/reperfusion (IRI) injury and myocardial fibrosis, and its activity and expression levels can regulate pathological cardiovascular diseases such as atherosclerosis, hypertension, cardiac hypertrophy, and heart failure. This article aims to review the structure and function of PKC-δ, summarize the current research regarding its activation mechanism and its role in cardiovascular disease, and provide novel insight into further research on the role of PKC-δ in cardiovascular diseases.

【 授权许可】

CC BY