Prognostic Value of Modified Model for End-Stage Liver Disease Score in Patients Undergoing Isolated Tricuspid Valve Replacement

Frontiers in Cardiovascular Medicine

article

Hongjie Xu¹  He Wang¹  Shisong Chen¹  Qian Chen¹  Tianyu Xu¹  Zhiyun Xu¹  Yangyong Sun¹ 

[1] Department of Cardiovascular Surgery, Changhai Hospital, Naval Medical University;Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University

关键词: ITVR;    TR;    hepatorenal dysfunction;    modified MELD score;    in-hospital prognosis;   

DOI  :  10.3389/fcvm.2022.932142

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Objective Though the prognostic value of the model for end-stage liver disease (MELD) score in tricuspid surgery was confirmed, the unstable international normalized ratio (INR) may affect the evaluation effectiveness of the MELD score for isolated tricuspid valve replacement (ITVR). The aim of the study was to assess the prognostic value of modified MELD for ITVR. Methods and Results A total of 152 patients who underwent ITVR were evaluated. The adverse outcome was defined as in-hospital mortality after surgery. The receiver operating characteristic (ROC) curve analysis demonstrated that a modified MELD score with albumin replacing INR (MELD-albumin) score presented well prognostic value [area under the curve (AUC) = 0.731, p = 0.006] for in-hospital mortality. Through Cox regression and further interval validation, the MELD-albumin score was identified as an independent predictor for in-hospital mortality. The optimal cutoff value of MELD-albumin was identified as 8.58 through maximally selected log-rank statistics. In addition, restricted cubic spline analysis demonstrated the linear inverse relationship between MELD-albumin and hazard ratio (HR) for in-hospital mortality. Kaplan–Meier analysis illustrated that in-hospital mortality was increased significantly in the high MELD-albumin (MELD-albumin ≥8.58) group than in the low MELD-albumin group (MELD-albumin <8.58; p < 0.001). Furthermore, high MELD-albumin was associated with lower body mass index (BMI), the incidence of lower extremities edema and moderate drinking history, and the MELD-albumin score was correlated with the value of aspartate transaminase (AST), alanine transaminase (ALT), and albumin. Furthermore, the incidence of renal failure ( p = 0.003) and pulmonary infection ( p = 0.042) was increased significantly in the high MELD-albumin group. Conclusion The MELD-albumin score could provide prognostic value for ITVR. In addition, the MELD-albumin score was useful in risk stratification and patient selection for patients with tricuspid regurgitation (TR) prior to ITVR.

【 授权许可】

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