A Tryptophan Metabolite of the Microbiota Improves Neovascularization in Diabetic Limb Ischemia

Frontiers in Cardiovascular Medicine

article

Xiurui Ma¹  Jinjing Yang¹  Guanrui Yang¹  Lei Li¹  Xiaojun Hao¹  Guoqin Wang¹  Jian An¹  Fei Wang¹ 

[1] Department of Cardiology, Shanxi Cardiovascular Hospital

关键词: diabetes mellitus;    limb ischemia;    indole-3-aldehyde;    mitochondrial dysfunction;    oxidative stress;    apoptosis;   

DOI  :  10.3389/fcvm.2022.910323

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Diabetes mellitus (DM) is accompanied by a series of macrovascular and microvascular injuries. Critical limb ischemia is the most severe manifestation of peripheral artery disease (PAD) caused by DM and is almost incurable. Therapeutic modulation of angiogenesis holds promise for the prevention of limb ischemia in diabetic patients with PAD. However, no small-molecule drugs are capable of promoting diabetic angiogenesis. An endogenous tryptophan metabolite, indole-3-aldehyde (3-IAld), has been found to have proangiogenic activity in endothelial cells. Nevertheless, the role of 3-IAld in diabetic angiogenesis remains unknown. Here, we found that 3-IAld ameliorated high glucose-induced mitochondrial dysfunction, decreasing oxidative stress and apoptosis and thus improving neovascularization.

【 授权许可】

CC BY