Non-linear Associations Between Visceral Adiposity Index and Cardiovascular and Cerebrovascular Diseases: Results From the NHANES (1999–2018)

Frontiers in Cardiovascular Medicine

article

Yangchang Zhang¹  Qiang He⁵  Weihao Zhang⁶  Yang Xiong⁷  Shisi Shen⁸  Jialu Yang¹  Mengliang Ye¹ 

[1] School of Public Health and Management, Chongqing Medical University;Research Center for Medicine and Social Development, Chongqing Medical University;The Innovation Center for Social Risk Governance in Health, Chongqing Medical University;Research Center for Public Health Security, Chongqing Medical University;Department of Neurosurgery, West China Hospital, Sichuan University;Department of Neurosurgery, The Affiliated Hospital of Guizhou Medical University, Guizhou Medical University;West China Hospital, Sichuan University;The First School of Clinical Medicine, Chongqing Medical University

关键词: visceral adiposity index;    angina;    heart attack;    stroke;    hypertension;    coronary heart disease;   

DOI  :  10.3389/fcvm.2022.908020

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Objective To investigate associations between visceral adiposity index (VAI) and cardiovascular and cerebrovascular diseases (CCDs) in the American population from 1999 to 2018. Methods Data from the National Health and Nutrition Examination Survey (1998–2018) were analyzed in this study. Specifically, VAI scores were calculated using sex-specific equations that incorporate body mass index, waist circumference (WC), high-density lipoprotein (HDL), triglycerides (TG), and cholesterol. Weighted logistic regression analysis was conducted to assess the relationship between VAI tertile and increased risk of CCDs. Restricted cubic splines were used to evaluate the non-linear relationship between VAI and CCDs, such as heart failure, angina, heart attack, stroke, hypertension, and coronary heart disease. Sensitivity analysis was conducted, using VAI quartiles as independent variables. Results A total of 22,622 subjects aged over 20 years were included. In the fully adjusted model after controlling for covariates, the third VAI tertile was more strongly associated with CCDs than the first VAI tertile, with odds ratio (OR) and 95% confidence interval (95% CI) values for angina of 2.86, 1.68–4.85; heart attack, 1.75, 1.14–2.69; stroke, 2.01, 1.23–3.26; hypertension, 2.28, 1.86–2.78; and coronary heart disease, 1.78, 1.32–2.41; but there was no significant association with heart failure ( p > 0.05). Restricted cubic splines revealed parabolic relationships between VAI score and angina ( p for non-linear = 0.03), coronary heart disease ( p for non-linear = 0.01), and hypertension ( p for non-linear < 0.001). Sensitivity analysis indicated that the fourth VAI quartile was more strongly associated with an increased risk of angina (OR = 2.92, 95% CI, 1.49–5.69), hypertension (OR = 2.37, 95% CI, 1.90–2.97), heart attack (OR = 1.77, 95% CI, 1.09–2.88), and coronary heart disease (OR = 1.89, 95% CI, 1.24–2.86) than the first VAI quartile. VAI had superior predictive power for prevalent CCDs than other independent indicators ( p < 0.05). Conclusion Visceral adiposity index score is positively correlated with angina, heart attack, stroke, hypertension, and coronary heart disease, but not heart failure, and the relationships between VAI score and angina, hypertension, and coronary heart disease are non-linear.

【 授权许可】

CC BY