Left Ventricular Diastolic Dysfunction Is Not Associated With Pulmonary Edema in Septic Patients. A Prospective Observational Cohort Study

Frontiers in Cardiovascular Medicine

article

Ursula Kahl¹  Leah Schirren¹  Yuanyuan Yu¹  Susanne Lezius²  Marlene Fischer¹  Maja Menke¹  Christoph Sinning⁴  Axel Nierhaus³  Maren Vens²  Christian Zöllner¹  Stefan Kluge³  Matthias S. Goepfert¹  Katharina Roeher¹ 

[1] Klinik und Poliklinik für Anästhesiologie Universitätsklinikum Hamburg-Eppendorf;Institut für Medizinische Biometrie und Epidemiologie Universitätsklinikum Hamburg-Eppendorf;Klinik für Intensivmedizin Universitätsklinikum Hamburg-Eppendorf;Klinik und Poliklinik für Kardiologie Universitäres Herz- und Gefäßzentrum Universitätsklinikum Hamburg-Eppendorf;Institut für Medizinische Biometrie und Statistik Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein Campus Lübeck;Klinik für Anästhesie und Intensivmedizin Alexianer St. Hedwigkliniken Berlin

关键词: diastolic dysfunction;    lung edema;    extravascular lung water;    pneumonia;    ultrasound;    echocardiography;    sepsis;   

DOI  :  10.3389/fcvm.2022.900850

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Purpose We aimed to investigate whether left ventricular diastolic dysfunction (LVDD) is associated with pulmonary edema in septic patients. Methods We conducted a prospective cohort study in adult septic patients between October 2018 and May 2019. We performed repeated echocardiography and lung ultrasound examinations within the first 7 days after diagnosis of sepsis. We defined LVDD according to the 2016 recommendations of the American Society of Echocardiography and—for sensitivity analysis—according to an algorithm which has been validated in septic patients. We quantified pulmonary edema using the lung ultrasound score (LUSS), counting B-lines in four intercostal spaces. Results We included 54 patients. LVDD was present in 51 (42%) of 122 echocardiography examinations. The mean (±SD) LUSS was 11 ± 6. There was no clinically meaningful association of LVDD with LUSS ( B = 0.55 [95%CI: −1.38; 2.47]; p = 0.571). Pneumonia was significantly associated with higher LUSS ( B = 4.42 [95%CI: 0.38; 8.5]; p = 0.033). Conclusion The lack of a clinically meaningful association of LVDD with LUSS suggests that LVDD is not a major contributor to pulmonary edema in septic patients.

【 授权许可】

CC BY