Changes in Impaired Fasting Glucose and Borderline High Low-Density Lipoprotein-Cholesterol Status Alter the Risk of Cardiovascular Disease: A 9-Year Prospective Cohort Study

Frontiers in Cardiovascular Medicine

article

Xianxuan Wang¹  Yan-Feng Zhou³  Zegui Huang¹  Xinran Yu⁴  Zekai Chen⁵  Zefeng Cai²  Yulong Lan²  Werijian Li¹  Zhiwei Cai¹  Wei Fang¹  Guanzhi Chen⁶  Weiqiang Wu²  Shouling Wu⁷  Youren Chen² 

[1] Second Clinical College, Shantou University Medical College;Department of Cardiology, Second Affiliated Hospital of Shantou University Medical College;Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology;Department of Anesthesiology, North China University of Science and Technology;Department of Epidemiology, University Medical Center Groningen, University of Groningen;Second Clinical College, China Medical University;Department of Cardiology, Kailuan General Hospital

关键词: impaired fasting glucose;    borderline high low-density lipoprotein-cholesterol;    cardiovascular disease;    dynamic changes;    cohort study;   

DOI  :  10.3389/fcvm.2022.882984

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Background We aimed to characterize the relationships of the changes in impaired fasting glucose (IFG) and borderline high low-density lipoprotein-cholesterol (LDL-C) status with cardiovascular disease (CVD). Methods A total of 36,537 participants who did not have previous CVD, diabetes mellitus, or high LDL-C (≥ 4.1 mmol/L), nor were taking lipid-lowering drugs were recruited from the Kailuan study. The participants were allocated to six groups according to their baseline and follow-up fasting blood glucose (FBG) and LDL-C concentrations: (1) both were normal; (2) both normal at baseline, one abnormality subsequently; (3) both normal at baseline, both abnormal subsequently; (4) at least one abnormality that became normal; (5) at least one abnormality at baseline, a single abnormality subsequently; and (6) at least one abnormality, two abnormalities subsequently. The outcomes were CVD and subtypes of CVD (myocardial infarction and stroke). Multiple Cox regression models were used to calculate adjusted hazard ratio (HR) and confidence interval (95% CI). Results During a median follow-up period of 9.00 years, 1,753 participants experienced a CVD event. After adjustment for covariates, participants with IFG in combination with a borderline high LDL-C status at baseline and follow-up had higher risks of CVD (HR: 1.52; 95% CI: 1.04–2.23 and HR: 1.38, 95% CI: 1.13–1.70, respectively) compared with those with normal fasting blood glucose and LDL-C. Compared with participants that remained normal, those who changed from normality to having two abnormalities were at a higher risk of CVD (HR: 1.26; 95% CI: 0.98–1.61), as were those who changed from at least one abnormality to two abnormalities (HR: 1.48, 95% CI: 1.02–2.15). Conclusion Changes in IFG and borderline high LDL-C status alter the risk of CVD and its subtype, implying that it is important to focus on such individuals for the prevention and control of CVD.

【 授权许可】

CC BY