Clinical Outcomes of Permanent Left Bundle Branch Area Pacing in Patients With Left Bundle Branch Block and Left Ventricular Ejection Fraction >35 vs. ≤35%

Frontiers in Cardiovascular Medicine

article

Zhixin Jiang¹  Tian Wu¹  Yixian Wu¹  Zenghong Chen¹  Wen Yang¹  Chongchong Chen¹  Xiujuan Zhou¹  Qijun Shan¹ 

[1] Department of Cardiology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University

关键词: left bundle branch block;    left bundle branch area pacing;    cardiac resynchronization therapy;    QRS duration;    heart failure;   

DOI  :  10.3389/fcvm.2022.838708

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Aims The present study aimed to compare the effects of left bundle branch area pacing (LBBAP) on cardiac function and clinical outcomes in patients with left bundle branch block (LBBB) and left ventricular ejection fraction (LVEF) >35 vs. ≤35%. Methods and Results Thirty-six consecutive patients with LBBB and LVEF 35% group (70 ± 8 years, 9 male), the success rate was 81.0% (17/21). QRSd significantly decreased from 174 ± 23 ms to 108 ± 13 ms ( P 35% group was 52.9%, which were almost twice of that in LVEF ≤ 35% group (33.3%). Whether patients had LBBAP or left ventricular septal pacing (LVSP), patients in the LVEF > 35% group showed significantly lower incidence of heart failure hospitalizations or death from any cause (hazard ratio in LVEF > 35% group, 0.22; 95%CI, 0.06 to 0.75, P = 0.011). Conclusions LBBAP can significantly shorten the QRSd and improve cardiac function in LBBB patients with either LVEF > 35 or ≤ 35%. LBBAP should be considered as an effective therapy for preventing the deterioration of cardiac function in early-stage heart failure patients with LBBB and LVEF > 35%.

【 授权许可】

CC BY