Long-Term Follow-Up of Subjects Without Overt Heart Disease With an Early Repolarization/J Wave Electrocardiographic Pattern

Frontiers in Cardiovascular Medicine

article

Gaetano Antonio Lanza¹  Veronica Melita¹  Antonio De Vita¹  Antonio Bisignani¹  Roberto Mollo¹  Filippo Crea¹ 

[1]Department of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore

关键词: electrocardiogram;    early repolarization;    J wave;    clinical outcome;    general population;   

DOI  :  10.3389/fcvm.2022.831381

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Aims The “early repolarization” (ER) pattern and J wave are frequent findings on standard ECG. Controversial data have recently been reported about their prognostic implications in healthy subjects, but no longitudinal prospective study specifically designed to investigate their long-term prognostic value has hitherto been published. Methods and Results We prospectively enrolled 4,176 consecutive subjects with no evidence of cardiovascular disease who were referred for standard ECG recording for routine check-ups or pre-operative assessments for non-cardiovascular surgery. ECGs were prospectively assessed for the presence of ER/J wave. A 10-year follow-up was available for 3,937 patients (94.3%), 660 of whom (16.8%) showed ER/J wave whereas 3,277 did not. A total of 644 deaths occurred (16.3%), 116 (2.95%) of which were attributed to cardiovascular causes. Both total and cardiovascular mortality adjusted for clinical and laboratory variables did not differ significantly between patients with vs. without ER/J wave (HR 0.94; 95% CI 0.75–1.19; p = 0.63 and HR 0.61; 95% CI 0.31–1.21; p = 0.16, respectively). No significant association with total and cardiovascular mortality was also found in pre-specified analyses for ER and J wave alone, ER/J wave detected in specific ECG regions (i.e., inferior, lateral, precordial), and type of J wave (notched or slurred). Conclusion In this specifically designed prospective study of individuals without any evidence of cardiovascular disease, we found no significant association of ER/J wave with the risk of the total as well as cardiovascular mortality during long-term follow-up.

【 授权许可】

CC BY