Serial Cardiovascular Magnetic Resonance Studies Prior to and After mRNA-Based COVID-19 Booster Vaccination to Assess Booster-Associated Cardiac Effects

Frontiers in Cardiovascular Medicine

article

Claudia Meier¹  Dennis Korthals¹  Michael Bietenbeck¹  Bishwas Chamling¹  Stefanos Drakos¹  Volker Vehof¹  Philipp Stalling¹  Ali Yilmaz¹ 

[1] Division of Cardiovascular Imaging, Department of Cardiology I, University Hospital Münster

关键词: COVID-19;    vaccination;    CMR;    MRI;    myocarditis;    t1-mapping;    t2-mapping;   

DOI  :  10.3389/fcvm.2022.877183

学科分类：地球科学(综合)

来源: Frontiers

【 摘 要 】

Background mRNA-based COVID-19 vaccination is associated with rare but sometimes serious cases of acute peri-/myocarditis. It is still not well known whether a 3rd booster-vaccination is also associated with functional and/or structural changes regarding cardiac status. The aim of this study was to assess the possible occurrence of peri-/myocarditis in healthy volunteers and to analyze subclinical changes in functional and/or structural cardiac parameters following a mRNA-based booster-vaccination. Methods and Results Healthy volunteers aged 18–50 years ( n = 41; m = 23, f = 18) were enrolled for a CMR-based serial screening before and after 3rd booster-vaccination at a single center in Germany. Each study visit comprised a multi-parametric CMR scan, blood analyses with cardiac markers, markers of inflammation and SARS-CoV-2-IgG antibody titers, resting ECGs and a questionnaire regarding clinical symptoms. CMR examinations were performed before (median 3 days) and after (median 6 days) 3rd booster-vaccination. There was no significant change in cardiac parameters, CRP or D-dimer after vaccination, but a significant rise in the SARS-CoV-2-IgG titer ( p < 0.001), with a significantly higher increase in females compared to males ( p = 0.044). No changes regarding CMR parameters including global native T1- and T2-mapping values of the myocardium were observed. A single case of a vaccination-associated mild pericardial inflammation was detected by T2-weighted CMR images. Conclusion There were no functional or structural changes in the myocardium after booster-vaccination in our cohort of 41 healthy subjects. However, subclinical pericarditis was observed in one case and could only be depicted by multiparametric CMR.

【 授权许可】

CC BY