The Role of 18 F-FLT PET/CT in Assessing Early Response to Transarterial Radioembolization and Chemoembolization in Patients with Primary and Metastatic Liver Tumors

Molecular Imaging and Radionuclide Therapy

article

Demet Nak¹  Nuriye Özlem Küçük²  Emre Can Çelebioğlu³  Mehmet Sadık Bilgiç³  Serhat Hayme⁴  Kemal Metin Kır² 

[1] Recep Tayyip Erdoğan Training and Research Hospital, Clinic of Nuclear Medicine;Ankara University Faculty of Medicine, Department of Nuclear Medicine;Ankara University Faculty of Medicine, Department of Radiology;Erzincan Binali Yıldırım University, Department of Biostatistics and Medical Informatics, Erzincan

关键词: 18F-FLT PET/CT;    early response;    primary;    metastatic;    chemoembolization;    liver tumors;    radioembolization;    TACE;    TARE;   

DOI  :  10.4274/mirt.galenos.2022.85579

来源: Turkiye Nukleer Tip Dernegi

【 摘 要 】

Objectives: Metastases and primary malignancies are common in the liver. Local ablative applications such as transarterial chemoembolization (TACE), and transarterial radioembolization (TARE) provide minimally invasive and safe treatment in unresectable liver tumors. Early detection of response to treatment prevents unnecessary toxicity and cost in non-responder patients and provides an earlier use of other options that may be effective. This study aimed to identify the role of 18 F-fluorothymidine (FLT) positron emission tomography/computed tomography (PET/CT) in the assessment of early response to TACE and TARE treatments in patients with unresectable primary and metastatic liver tumors Methods: This single-center study included 63 patients who underwent 18 F-FLT PET/CT for response evaluation after TACE and TARE. After excluding 20 patients whose data were missing 43 TARE-receiving patients were analyzed. The compatibility of change in semi-quantitative values obtained from the 18 F-FLT PET/CT images with the treatment responses detected in 18 F-fluorodeoxyglucose PET/CT, CT, and MR images and survival was evaluated. Results: There was no correlation between early metabolic, morphological response, and 18 F-FLT uptake pattern, and change in standardized uptake values (SUV) which were ΔSUV max , ΔSUV mean , ΔSUV peak ., ΔSUV mean , Δ SUV peak values. There was no significant correlation between 18 F-FLT uptake pattern, ΔSUV max , ΔSUV mean , ΔSUV peak , and overall survival, progression-free survival (PFS) for the target lobe PFS for the whole-body. The survival distributions for the patients with >30% change in Δ SUV max and ΔSUV peak values were statistically significantly longer than the patients with <30% change (p<0.009 and p<0.024, respectively). Conclusion: There was significant longer PFS for target liver lobe in patients with more than 30% decrease in 18 F-FLT SUV max and SUV peak of the liver lesion in primary and metastatic unresectable liver tumors undergoing TARE.

【 授权许可】

Unknown