Sentinel Lymph Node Mapping: Current Applications and Future Perspectives in Gynecology Malignant Tumors

Frontiers in Medicine

article

Tianyou Wang¹  Yan Xu¹  Wenyu Shao¹  Chao Wang¹ 

[1] Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital, Fudan University

关键词: sentinel lymph node;    mapping;    cervical cancer;    ovarian cancer;    endometrial cancer;    vulvar cancer;    gynecological cancer;    clinical trials;   

DOI  :  10.3389/fmed.2022.922585

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

The sentinel lymph nodes (SLNs) is a group of lymph nodes initially involved in the metastatic spread of cancer cells. SLN mapping refers to intraoperative localization and biopsy of SLNs with specific tracers to assess lymph node metastases. It is widely used in a variety of tumor surgeries for its high sensitivity and high negative predictive value. In the evaluation of the status of lymph node metastases in gynecological malignancies, it has received increasingly more attention due to its minor invasiveness, few complications, and high diagnosis rate. The National Comprehensive Cancer Network (NCCN) guidelines provide an excellent introduction to the indications and methods of SLN techniques in vulvar, cervical, and endometrial cancers, but they provide little explanation about some specific issues. In this review, we summarize different dyes and injection methods and discuss the indications of application and the clinical trials of SLN mapping in gynecological malignant tumors, aiming to provide a reference for the rational application of sentinel techniques in gynecology malignant tumors before relevant guidelines are updated.

【 授权许可】

CC BY