Endothelial Activation and Microcirculatory Disorders in Sepsis

Frontiers in Medicine

article

Lisa Raia¹  Lara Zafrani¹ 

[1] Medical Intensive Care Unit, Hôpital Saint-Louis;INSERM UMR 976, University of Paris Cité

关键词: endothelial dysfunction;    sepsis;    microcirculation;    organ failure;    peripheral perfusion;    endothelium;   

DOI  :  10.3389/fmed.2022.907992

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

The vascular endothelium is crucial for the maintenance of vascular homeostasis. Moreover, in sepsis, endothelial cells can acquire new properties and actively participate in the host's response. If endothelial activation is mostly necessary and efficient in eliminating a pathogen, an exaggerated and maladaptive reaction leads to severe microcirculatory damage. The microcirculatory disorders in sepsis are well known to be associated with poor outcome. Better recognition of microcirculatory alteration is therefore essential to identify patients with the worse outcomes and to guide therapeutic interventions. In this review, we will discuss the main features of endothelial activation and dysfunction in sepsis, its assessment at the bedside, and the main advances in microcirculatory resuscitation.

【 授权许可】

CC BY