The Role of Quantitative and Semi-quantitative [ 18 F]FDG-PET/CT Indices for Evaluating Disease Activity and Management of Patients With Dermatomyositis and Polymyositis

Frontiers in Medicine

article

Olivier Gheysens¹  Halil Yildiz²  Philippe D'abadie¹ 

[1] Department of Nuclear Medicine, Cliniques Universitaires Saint-Luc and Institute of Clinical and Experimental Research ,(IREC), Université Catholique de Louvain;Department of Internal Medicine and Infectious Diseases, Cliniques Universitaires Saint-Luc and Institute of Clinical and Experimental Research ,(IREC), Université Catholique de Louvain

关键词: [ 18 F]FDG-PET/CT;    dermatomyositis;    polymyositis;    cancer;    interstitial lung disease;    standardized uptake value;   

DOI  :  10.3389/fmed.2022.883727

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Idiopathic inflammatory myopathies (IIM) are considered systemic diseases involving different organs and some subtypes are associated with increased cancer risk. In this review, we provide a comprehensive summary of the current use and potential applications of (semi-)quantitative [ 18 F]FDG-PET/CT indices in patients with IIM focusing on dermatomyositis and polymyositis. Visual interpretation and (semi-)quantitative [ 18 F]FDG-PET indices have a good overall performance to detect muscle activity but objective, robust and standardized interpretation criteria are currently lacking. [ 18 F]FDG-PET/CT is a suitable modality to screen for malignancy in patients with myositis and may be a promising tool to detect inflammatory lung activity and to early identify patients with rapidly progressive lung disease. The latter remains to be determined in large, prospective comparative trials.

【 授权许可】

CC BY