Unmet Medical Needs in Chronic, Non-communicable Inflammatory Skin Diseases

Frontiers in Medicine

article

Hideyuki Ujiie¹  David Rosmarin²  Michael P. Schön³  Sonja Ständer⁵  Katharina Boch⁶  Martin Metz⁷  Marcus Maurer⁷  Diamant Thaci⁹  Enno Schmidt⁶  Connor Cole^1,11  Kyle T. Amber^1,11  Dario Didona^1,13  Michael Hertl^1,13  Andreas Recke⁶  Hanna Graßhoff^1,14  Alexander Hackel^1,14  Anja Schumann^1,14  Gabriela Riemekasten^1,14  Katja Bieber^1,10  Gant Sprow^1,15  Joshua Dan^1,15  Detlef Zillikens⁶  Tanya Sezin^1,17  Angela M. Christiano^1,17  Kerstin Wolk^1,18  Robert Sabat^1,18  Khalaf Kridin^1,10  Victoria P. Werth^1,15  Ralf J. Ludwig⁶ 

[1] Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University;Department of Dermatology, Tufts Medical Center;Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen;Lower Saxony Institute of Occupational Dermatology, University Medical Center Göttingen;Center for Chronic Pruritus, Department of Dermatology, University Hospital Muenster;Department of Dermatology, University of Lübeck;Institute for Allergology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin;Fraunhofer Institute for Translational Medicine and Pharmacology;Institute and Comprehensive Center for Inflammation Medicine, University of Lübeck;Lübeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck;Division of Dermatology, Rush University Medical Center;Department of Internal Medicine, Rush University Medical Center;Department of Dermatology and Allergology, Philipps-Universität;Department of Rheumatology and Clinical Immunology, University of Lübeck;Department of Dermatology, Perelman School of Medicine, University of Pennsylvania;Corporal Michael J. Crescenz Veterans Affairs Medical Center;Department of Dermatology, Columbia University Medical Center;Psoriasis Research and Treatment Centre, Charité—Universitätsmedizin Berlin;Interdisciplinary Group Molecular Immunopathology, Dermatology/Medical Immunology, Charité—Universitätsmedizin Berlin;Azrieli Faculty of Medicine, Bar-Ilan University

关键词: medical need;    skin;    inflammation;    atopic dermatitis;    psoriasis;    alopecia areata;    chronic spontaneous urticaria;    hidradenitis suppurativa;   

DOI  :  10.3389/fmed.2022.875492

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

An estimated 20–25% of the population is affected by chronic, non-communicable inflammatory skin diseases. Chronic skin inflammation has many causes. Among the most frequent chronic inflammatory skin diseases are atopic dermatitis, psoriasis, urticaria, lichen planus, and hidradenitis suppurativa, driven by a complex interplay of genetics and environmental factors. Autoimmunity is another important cause of chronic skin inflammation. The autoimmune response may be mainly T cell driven, such as in alopecia areata or vitiligo, or B cell driven in chronic spontaneous urticaria, pemphigus and pemphigoid diseases. Rare causes of chronic skin inflammation are autoinflammatory diseases, or rheumatic diseases, such as cutaneous lupus erythematosus or dermatomyositis. Whilst we have seen a significant improvement in diagnosis and treatment, several challenges remain. Especially for rarer causes of chronic skin inflammation, early diagnosis is often missed because of low awareness and lack of diagnostics. Systemic immunosuppression is the treatment of choice for almost all of these diseases. Adverse events due to immunosuppression, insufficient therapeutic responses and relapses remain a challenge. For atopic dermatitis and psoriasis, a broad spectrum of innovative treatments has been developed. However, treatment responses cannot be predicted so far. Hence, development of (bio)markers allowing selection of specific medications for individual patients is needed. Given the encouraging developments during the past years, we envision that many of these challenges in the diagnosis and treatment of chronic inflammatory skin diseases will be thoroughly addressed in the future.

【 授权许可】

CC BY