Functional Optical Coherence Tomography for Intrinsic Signal Optoretinography: Recent Developments and Deployment Challenges

Frontiers in Medicine

article

Tae-Hoon Kim¹  Guangying Ma¹  Taeyoon Son¹  Xincheng Yao¹ 

[1] Richard and Loan Hill Department of Biomedical Engineering, University of Illinois at Chicago;Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago

关键词: optoretinography;    intrinsic optical signal imaging;    retina;    phototransduction;    optical coherence tomography;    retinography;    functional retinal imaging;    photoreceptor;   

DOI  :  10.3389/fmed.2022.864824

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Intrinsic optical signal (IOS) imaging of the retina, also termed as optoretinogram or optoretinography (ORG), promises a non-invasive method for the objective assessment of retinal function. By providing the unparalleled capability to differentiate individual retinal layers, functional optical coherence tomography (OCT) has been actively investigated for intrinsic signal ORG measurements. However, clinical deployment of functional OCT for quantitative ORG is still challenging due to the lack of a standardized imaging protocol and the complication of IOS sources and mechanisms. This article aims to summarize recent developments of functional OCT for ORG measurement, OCT intensity- and phase-based IOS processing. Technical challenges and perspectives of quantitative IOS analysis and ORG interpretations are discussed.

【 授权许可】

CC BY