Synovial Macrophage and Fibroblast Heterogeneity in Joint Homeostasis and Inflammation

Frontiers in Medicine

article

Katharina Knab¹  David Chambers¹  Gerhard Krönke¹ 

[1] Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander University Erlangen-Nürnberg ,(FAU), Universitätsklinikum Erlangen;Deutsches Zentrum für Immuntherapie ,(DZI), Friedrich-Alexander University Erlangen-Nürnberg ,(FAU), Universitätsklinikum Erlangen

关键词: macrophages;    fibroblasts;    rheumatoid arthritis;    synovial tissue;    single-cell sequencing;    inflammation;   

DOI  :  10.3389/fmed.2022.862161

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

The synovial tissue is an immunologically challenging environment where, under homeostatic conditions, highly specialized subsets of immune-regulatory macrophages and fibroblasts constantly prevent synovial inflammation in response to cartilage- and synovial fluid-derived danger signals that accumulate in response to mechanical stress. During inflammatory joint diseases, this immune-regulatory environment becomes perturbed and activated synovial fibroblasts and infiltrating immune cells start to contribute to synovial inflammation and joint destruction. This review summarizes our current understanding of the phenotypic and molecular characteristics of resident synovial macrophages and fibroblasts and highlights their crosstalk during joint homeostasis and joint inflammation, which is increasingly appreciated as vital to understand the molecular basis of prevalent inflammatory joint diseases such as rheumatoid arthritis.

【 授权许可】

CC BY