Endothelial Dysfunction in Systemic Lupus Erythematosus and Systemic Sclerosis: A Common Trigger for Different Microvascular Diseases

Frontiers in Medicine

article

Liala Moschetti¹  Silvia Piantoni¹  Enrico Vizzardi²  Edoardo Sciatti³  Mauro Riccardi²  Franco Franceschini¹  Ilaria Cavazzana¹ 

[1] Rheumatology and Clinical immunology Unit, ASST Spedali Civili of Brescia, Department of Clinical and Experimental Sciences, University of Brescia;Cardiology Unit, ASST Spedali Civili of Brescia, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia;Cardiology Unit 1

关键词: endothelial dysfunction;    systemic lupus erythematosus;    systemic sclerosis;    microvascular disease;    techniques of assessment;   

DOI  :  10.3389/fmed.2022.849086

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

This review describes the complex interplay between inflammation, vasculopathy and fibrosis that involve the heart and peripheral small vessels, leading to endothelial stiffness, vascular damage, and early aging in patients with systemic lupus erythematosus and systemic sclerosis, which represents two different models of vascular dysfunction among systemic autoimmune diseases. In fact, despite the fact that diagnostic methods and therapies have been significantly improved in the last years, affected patients show an excess of cardiovascular mortality if compared with the general population. In addition, we provide a complete overview on the new techniques which are used for the evaluation of endothelial dysfunction in a preclinical phase, which could represent a new approach in the assessment of cardiovascular risk in these patients.

【 授权许可】

CC BY